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Funding has been secured to start building new social housing in Plymouth.

Plymouth Community Homes (PCH) said the city council had been given £5m from the government which, combined with £14.2m of loans and subsidies it had raised, would enable the work on the £33.5m scheme in Millbay to begin.

PCH said the first phase would start in February or March in which 80 homes for social rent would be built on land off Bath Street. Planning permission for up to 135 affordable homes has been granted.

Andrew Lawrie, PCH head of development, said finalising the funding had been “a tremendous outcome” as it would enable the group to deliver “a large number of much-needed new homes”.

He said the scheme would create “a brand new community” for people on the waiting list for a social home, together with communal gardens, children’s play area and business units.

The new homes will be a mix of one and two-bedroom apartments and three-bedroom houses and will be available to households on the Devon Home Choice waiting list, he added.

Completion of the first 80 homes has been estimated to take place by early 2029.

Plymouth City Council said ground investigation works would be taking place on the site before construction works could start and the Martin Street car park would be closed from Friday 31 October.

Welcome to this week’s edition of The Targeted Pulse, your weekly wrap-up of the top developments in oncology. This week, we saw several breakthroughs in targeted therapies and FDA decisions, bringing renewed hope to patients and clinicians alike. From regulatory designations for promising new drugs to crucial clinical trials, here are the top stories that shaped the week.

Low-Dose Nivolumab Offers Novel Strategy for Hodgkin Lymphoma Treatment

A phase 2 study found that a low-dose regimen of the immunotherapy drug nivolumab (Opdivo; 40 mg) combined with lenalidomide is a highly effective, chemotherapy-free strategy for classical Hodgkin lymphoma (cHL). The combination achieved an overall response rate of 90% with a favorable safety profile.

Crucially, researchers observed that the 40 mg dose was sufficient to achieve complete PD-1 receptor occupancy, suggesting that the standard, higher nivolumab dosing may be excessive. The findings advocate for using pharmacodynamic biomarkers to guide personalized, cost-effective dosing schedules. This evidence-based approach challenges traditional dosing models, offering a path to significantly reduce treatment costs and improve global access to nivolumab, especially in resource-limited areas. A phase 3 trial is currently underway to compare this novel low-dose regimen with the standard ABVD chemotherapy.

FDA Approves Lurbinectedin/Atezolizumab for ES-SCLC Maintenance

The FDA has approved the combination of lurbinectedin (Zepzelca) and the immunotherapy atezolizumab (Tecentriq) for first-line maintenance treatment in patients with extensive-stage small cell lung cancer (ES-SCLC). This regimen is for patients whose disease has not progressed after initial induction therapy.

The approval is based on the phase 3 IMforte trial, which demonstrated statistically significant improvements in survival. Compared to atezolizumab alone, the combination reduced the risk of disease progression or death by 46% and the risk of death by 27%, with a median overall survival of 13.2 months. This maintenance strategy addresses a critical need in ES-SCLC to proactively prevent aggressive relapse.

FDA Approves Cemiplimab for Adjuvant Cutaneous Squamous Cell Carcinoma

The FDA has approved the immunotherapy cemiplimab-rwlc (Libtayo) as the first and only adjuvant treatment for adults with high-risk cutaneous squamous cell carcinoma (CSCC) following surgery and radiation.

This approval is based on the phase 3 C-POST study, which demonstrated that cemiplimab significantly improved disease-free survival (DFS). The treatment reduced the risk of cancer recurrence or death by 68% compared with placebo, addressing a critical unmet need for patients with a high risk of relapse. The findings also showed an 80% reduction in locoregional recurrence risk, marking a practice-changing milestone in preventing recurrence for this vulnerable population.

Orca-T Earns FDA Priority Review in Heme Malignancies

The FDA granted priority review to the biologics license application (BLA) for Orca-T, an investigational allogeneic T-cell immunotherapy for treating high-risk hematologic malignancies, including AML, ALL, and MDS. The priority review is based on data from the phase 3 Precision-T study. This trial showed that Orca-T significantly improved patient outcomes compared to standard allogeneic hematopoietic stem cell transplant (alloHSCT), particularly in achieving survival free of chronic graft-vs-host disease (cGVHD). Specifically, Orca-T achieved a high survival rate with a much lower incidence of moderate to severe cGVHD (13% vs 44%). This milestone aims to provide a potentially curative option with reduced treatment-related complications.

Dato-DXd Delivers Significant TNBC Survival Benefits in Phase 3 Trial

The antibody-drug conjugate (ADC) datopotamab deruxtecan (Dato-DXd; Datroway) showed statistically significant improvements in both overall survival (OS) and progression-free survival (PFS) for the first-line treatment of metastatic triple-negative breast cancer (TNBC). The pivotal phase 3 TROPION-Breast02 trial demonstrated that Dato-DXd was superior to standard chemotherapy for patients for whom immunotherapy was not a treatment option. This is the first trial to show an OS benefit in this challenging patient population, suggesting a potential shift in the standard of care for a disease often associated with a poor prognosis.

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The continuing US government shutdown has stopped official data releases, which will leave investors without the September inflation data that had been scheduled for publication on Wednesday.

Economists polled by Bloomberg had expected the consumer price index from the Bureau of Labor Statistics to show an increase in inflationary pressures. Instead, the BLS said on Friday that it planned to release its data on October 24.

The CPI release, while more than a week late, will still come in time for the Federal Reserve’s rate-setters, which next meet on October 28-29, to factor it into their policy decision. At their last meeting, they signalled a greater focus on the risks from a slowing labour market than from rising inflation. The “dot plot”, the Fed’s survey of its own members’ forecasts, suggests that policymakers expect inflation to be running at 3 per cent by year-end, slightly above the current rate.

The absence of inflation data could keep investors from making big moves in markets. In place of the BLS data, many have resorted to a slew of private data providers alongside survey data from the Fed, such as its “beige book”, for insights into the US economy.

Still, President Donald Trump’s Truth Social post on Friday promising new tariffs on China led to a drop in stocks and a jump in volatility, suggesting that if the risks are high enough, some investors may jump, with or without the economic data to hand. Kate Duguid

How healthy is the UK economy?

Investors will scrutinise UK labour market data on Tuesday and GDP figures on Thursday for insights into underlying inflation pressures and the health of the economy.

Economists polled by Reuters expect annual wage growth (excluding bonuses) for the three months to August to edge down to 4.7 per cent, from 4.8 per cent in the three months to July. They expect the unemployment rate to be unchanged at 4.7 per cent.

Bank of England policymakers are concerned that wage growth is running too hot for their 2 per cent inflation target, particularly given the UK’s weak productivity record.

While the labour market figures remain uncertain because of poor survey response rates in recent years, analysts will focus on whether recent declines in employment are enough to cool wage growth. A sharp slowdown in wages and a deterioration in hiring could reinforce expectations of interest rate cuts in 2026.

Markets are pricing that the BoE will make one or two quarter-percentage-point cuts next year.

As for the GDP data, economists expect month-on-month growth in August of 0.1 per cent, up from zero growth in July, taking the three-month-on-three-month rate — now the Office for National Statistics’ preferred measure — to 0.3 per cent, up from 0.2 per cent previously.

Ellie Henderson, economist at Investec, also forecasts marginally stronger growth in August but said tax increases expected in the November Budget would have an impact on activity in the autumn.

“Various surveys suggest the prospect of fiscal tightening is already prompting households and firms to delay spending and investment,” she said. “Speculation around the scale of adjustment needed is likely to grow in the run-up to [the Budget on November 26], acting as a further drag on output.” Valentina Romei

Will China’s trade surplus keep defying gravity?

Chinese exports are expected to jump again when Beijing reports trade figures for September on Monday, as the outward flow of goods continues to swell despite the Trump administration’s tariffs.

Economists expect Beijing to report a year-on-year rise of 7.1 per cent in exports during the month, up from 4.4 per cent growth in September. With imports seen rising at a 1.5 per cent pace (up slightly from 1.3 per cent), China’s monthly trade surplus is expected to come in at a hefty $100bn.

The persistently strong figures have defied many economists’ expectations that China’s export machine would slow as Trump’s tariffs took effect — especially since the weakening dollar has sent the renminbi up 2.4 per cent against the greenback this year.

However, a growing chorus of analysts has pointed out that, on a trade-weighted basis, the renminbi is depreciating. It has fallen 8.6 per cent this year against the euro, for example, making exports to Europe more competitive.

China’s trade surplus with the Eurozone is growing rapidly. For the first eight months of the year, exports to the continent grew 5.4 per cent, while imports fell 9.9 per cent. China’s shipments of steel and textiles, for example, have surged, adding to trade tensions.

Jacqueline Rong, chief China economist at BNP Paribas, said China’s resilient exports to non-US markets were down to more than rerouting of trade with the US. The robust growth of its exports to Europe, she said, has been “driven mostly by China’s gain in market share . . . rather than trans-shipments.” William Sandlund